作为医药中间体，用于合成相关药物。
医药
合成路线 1（1. 合成：179688-27-8）
产率：99%
合成条件：With hydrazine hydrate In N,N-dimethyl-formamide at 100℃; for 3 h; Green chemistry
实验步骤：通用方法：将有机硝基化合物（1.0mmol），NH 2 NH 2·H 2 O（2.5当量）和H 2 O 2处理的AC粉末（50wt％）在DMF（1.5mL）中的混合物在100℃下剧烈磁力搅拌。 通过LC-MS或GC-MS监测反应。 完成后，过滤反应混合物以除去催化剂。 将合并的有机混合物材料用无水Na 2 SO 4干燥并过滤。 减压除去溶剂，得到产物。 所有化合物均已知，并通过1H NMR和MS谱表征，并与文献数据进行比较。
参考文献：
- [1] Journal of Chemical Research, 2017, vol. 41, # 9, p. 509 - 512 [2] Patent: CN107382880, 2017, A. Location in patent: Paragraph 0028 [3] Research on Chemical Intermediates, 2013, vol. 39, # 6, p. 2303 - 2309 [4] Patent: CN103709110, 2016, B. Location in patent: Paragraph 0065; 0066 [5] Journal of Labelled Compounds and Radiopharmaceuticals, 2005, vol. 48, # 11, p. 829 - 843 [6] Patent: EP1650196, 2006, A1. Location in patent: Page/Page column 7 [7] Patent: EP1614676, 2006, A1. Location in patent: Page/Page column 194-195 [8] Patent: CN108358798, 2018, A. Location in patent: Paragraph 0052; 0062; 0068; 0071-0072; 0082; 0105-0111; 0122 [9] Patent: US2010/267949, 2010, A1. Location in patent: Page/Page column 7 [10] European Journal of Medicinal Chemistry, 2008, vol. 43, # 7, p. 1478 - 1488 [11] Molecules, 2006, vol. 11, # 4, p. 286 - 297 [12] European Journal of Medicinal Chemistry, 2013, vol. 67, p. 293 - 301 [13] Patent: CN103193722, 2016, B. Location in patent: Paragraph 0112; 0113; 0114 [14] Journal of Labelled Compounds and Radiopharmaceuticals, 2018, vol. 61, # 2, p. 42 - 53
