化学合成。
2-溴噻唑-4-甲酸乙酯是一种有机中间体，可由3-溴丙酮酸乙酯和硫脲作为起始物料通过两步制备得到。2-溴噻唑-4-甲酸乙酯可用于制备FXa抑制剂噻唑-4-甲酰基哌嗪衍生物。
合成路线 1（1. 合成：100367-77-9）
产率：84%
合成条件：With 2-Methyl-2-nitropropane; copper(ll) bromide In acetonitrile at 0 - 20℃; for 12 h;
实验步骤：在0℃下，向2-氨基噻唑-4-羧酸乙酯（100g，581mmol）和溴化铜（II）（195g，871mmol）的乙腈（1000ml）溶液中加入亚硝酸叔丁酯（104ml， 逐滴加入871mmol）。 将反应混合物温热至室温并搅拌12小时。 完成反应后，将反应混合物用乙酸乙酯（1000ml）和水（3000ml）的混合物稀释，然后用1N盐酸酸化至pH2。 分离两层，水层再次用乙酸乙酯（500ml）萃取三次。 将合并的有机层用无水硫酸钠干燥，过滤并减压浓缩。 通过从己烷中重结晶纯化粗产物，得到纯的2-溴-1,3-噻唑-4-羧酸乙酯（115g，84％收率）.1H-NMR（400MHz，DMSO-d6）8.52（s， IH），4.29（q，J 7.1Hz，2H），1.29（t，J 7.1Hz，3H）MS：m / z 235.90。[M+ 1]。
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