6935-44-0 (E)-2-氰基-3-(4-羟基苯基)丙烯酸乙酯

危险性质：非危险化学品

化学合成。

化学合成

合成路线 1（1. 合成：6935-44-0）

产率：99% 合成条件：With polymer supported poly(propylene imine)dendrimer In ethanol at 20℃; for 0.17 h; Green chemistry 实验步骤：通用方法：将醛（5mmol），活性亚甲基化合物（5mmol），聚合物负载催化剂（25mg，0.5mol％底物）和无水乙醇（5mL）在底部烧瓶中混合并在室温下搅拌 温度。 通过TLC在硅胶板上监测反应进程，使用己烷-EtOAc（10：1）作为洗脱剂。 在反应完成后，使用滤纸过滤反应混合物，并将收集在滤纸中的催化剂用乙醇洗涤数次。 合并洗涤液和滤液，减压蒸发，分离产物。 通常，产物以高纯度获得，不需要进一步纯化。 先前报道了所有产物，并通过熔点测定FTIR光谱和1HNMR光谱表征。 参考文献：

• [1] Tetrahedron Letters, 2014, vol. 55, # 15, p. 2352 - 2354 [2] Synlett, 2016, vol. 27, # 9, p. 1433 - 1437 [3] Tetrahedron, 2000, vol. 56, # 47, p. 9357 - 9364 [4] Synthetic Communications, 2003, vol. 33, # 5, p. 783 - 788 [5] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 3, p. 390 - 393 [6] Journal of the Korean Chemical Society, 2011, vol. 55, # 6, p. 1000 - 1006 [7] Green Chemistry, 2013, vol. 15, # 9, p. 2349 - 2355 [8] Tetrahedron Letters, 2017, vol. 58, # 50, p. 4691 - 4694 [9] Catalysis Letters, 2018, vol. 148, # 6, p. 1703 - 1713 [10] Synthetic Communications, 1997, vol. 27, # 4, p. 533 - 541 [11] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2013, vol. 52, # 5, p. 694 - 697 [12] Research on Chemical Intermediates, 2015, vol. 41, # 10, p. 7847 - 7882 [13] Catalysis Letters, 2018, vol. 148, # 1, p. 194 - 204 [14] Synthetic Communications, 2003, vol. 33, # 13, p. 2309 - 2312 [15] Journal of Chemical Research, 2006, # 6, p. 346 - 347 [16] Synthetic Communications, 2011, vol. 41, # 20, p. 3060 - 3065 [17] Journal of Chemical Research, 2012, vol. 36, # 7, p. 429 - 431 [18] Chinese Chemical Letters, 2012, vol. 23, # 9, p. 1067 - 1070 [19] Research on Chemical Intermediates, 2017, vol. 43, # 8, p. 4813 - 4832 [20] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2010, vol. 49, # 10, p. 1428 - 1431 [21] Asian Journal of Chemistry, 2014, vol. 26, # 7, p. 1938 - 1942 [22] Synthetic Communications, 2012, vol. 42, # 3, p. 412 - 423 [23] Catalysis Today, 2013, vol. 200, # 1, p. 17 - 23 [24] Applied Organometallic Chemistry, 2017, vol. 31, # 7, [25] Journal of Chemical Research - Part S, 2001, # 5, p. 188 - 189 [26] Catalysis Communications, 2010, vol. 11, # 8, p. 679 - 683 [27] Journal of Molecular Catalysis A: Chemical, 2016, vol. 415, p. 74 - 81 [28] Journal of Molecular Catalysis A: Chemical, 2011, vol. 339, # 1-2, p. 24 - 31 [29] RSC Advances, 2018, vol. 8, # 53, p. 30180 - 30185 [30] Bulletin of the Korean Chemical Society, 2010, vol. 31, # 5, p. 1301 - 1304 [31] Tetrahedron Letters, 2017, vol. 58, # 32, p. 3183 - 3187 [32] Catalysis Today, 2012, vol. 185, # 1, p. 211 - 216 [33] Synthetic Communications, 2007, vol. 37, # 13, p. 2209 - 2213 [34] New Journal of Chemistry, 2013, vol. 37, # 2, p. 269 - 273 [35] Beilstein Journal of Organic Chemistry, 2009, vol. 5, [36] Synthetic Communications, 2006, vol. 36, # 16, p. 2407 - 2412 [37] Synthetic Communications, 2004, vol. 34, # 16, p. 2965 - 2971 [38] Synthetic Communications, 2004, vol. 34, # 11, p. 2047 - 2051 [39] Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1994, vol. 33, # 7, p. 657 - 661 [40] Synthetic Communications, 2001, vol. 31, # 5, p. 673 - 677 [41] RSC Advances, 2016, vol. 6, # 64, p. 59574 - 59581 [42] Journal fuer Praktische Chemie (Leipzig), 1896, vol. <2> 54, p. 547 [43] Egyptian Journal of Chemistry, 2007, vol. 50, # 3, p. 287 - 302 [44] Asian Journal of Chemistry, 2011, vol. 23, # 2, p. 684 - 686 [45] Catalysis Communications, 2011, vol. 15, # 1, p. 78 - 81 [46] Applied Catalysis A: General, 2012, vol. 413-414, p. 205 - 212 [47] Monatshefte fur Chemie, 2010, vol. 141, # 10, p. 1101 - 1106 [48] Monatshefte fur Chemie, 2012, vol. 143, # 7, p. 1075 - 1086 [49] Chemistry - A European Journal, 2012, vol. 18, # 40, p. 12773 - 12782 [50] Applied Organometallic Chemistry, 2013, vol. 27, # 2, p. 73 - 78 [51] ChemCatChem, 2013, vol. 5, # 1, p. 331 - 338 [52] Catalysis Communications, 2013, vol. 35, p. 110 - 114 [53] Research on Chemical Intermediates, 2014, vol. 40, # 1, p. 67 - 75 [54] Australian Journal of Chemistry, 2013, vol. 66, # 8, p. 913 - 920 [55] Russian Chemical Bulletin, 2009, vol. 58, # 11, p. 2397 - 2399 [56] Izvestiya Akademii Nauk. Seriya Khimicheskaya, 2009, # 11, p. 2320 - 2322,3 [57] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 15, p. 3285 - 3290 [58] ChemCatChem, 2015, vol. 7, # 6, p. 993 - 1003 [59] Chinese Journal of Catalysis, 2015, vol. 36, # 7, p. 1093 - 1100 [60] Journal of the Iranian Chemical Society, 2015, vol. 12, # 7, p. 1261 - 1273 [61] Journal of Organometallic Chemistry, 2019, p. 322 - 332