2725-53-3 5-(叔丁基)-2-羟基苯甲醛

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合成路线 3（3. 合成：2725-53-3）

产率：42.5% 合成条件：With sodium hydroxide In water for 8 h; Inert atmosphere; Reflux 实验步骤：向配有回流冷凝器，温度计，氮源和磁力搅拌器的三颈烧瓶中加入对叔丁基苯酚（16mmol），氢氧化钠（100mmol），蒸馏水（40mL）和氯仿（7.0mL）。。 将混合物加热至回流8小时。 冷却后，用2M盐酸将反应混合物酸化至pH2-3，并用乙酸乙酯萃取。 通过TLC监测反应。 用真空蒸馏处理乙酸乙酯提取物，得到粗5-叔丁基水杨醛。 通过柱色谱法纯化粗产物，得到棕黄色液体产物（1.183g，42.5％）。 参考文献：

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