17100-58-2 (4-溴-2-甲基苯基)甲醇

危险性质：非危险化学品

化学合成。

化学合成; 抗肿瘤药物中间体; 光敏材料制备; 醇氧化酶制备; 蛋白质及DNA标记探针制备

合成路线 1（1. 合成：17100-58-2）

产率：100% 合成条件：Stage #1: With borane-THF In tetrahydrofuran at 0 - 20℃; for 3 h; Stage #2: With water; sodium hydrogencarbonate In tetrahydrofuran 实验步骤：步骤a，将中间体50（4-溴-2-甲基苯基）甲醇4-溴-2-甲基苯甲酸（11.1g，51.6mmol）溶于无水THF（11.2mL）中。 将溶液冷却至0-5℃和1M的BH3溶液。 将THF（103mL）加入混合物中。 将溶液在室温下搅拌3小时。 然后加入冷水（20mL）并将反应混合物用饱和NaHCO 3溶液（120mL）洗涤。 水相用乙醚（3×300mL）萃取，合并的有机相用盐水（200mL）洗涤，用MgSO 4干燥并真空浓缩。 所得油状物通过快速色谱法纯化，用己烷/ EtOAc从95：5至70:30洗脱，得到预期产物（4-溴-2-甲基苯基）甲醇（10.4g，100％），为透明油状物。 1H NMR（300MHz，氯仿-D）：δ7.36-7.30（2H，m），7.25-7.21（1H，m），4.65（2H，s）2.32（3H，s）。 参考文献：

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