作为医药中间体或活性成分，用于相关药物研发与生产。
医药
合成路线 1（1. 合成：1316216-05-3）
产率：38%
合成条件：With caesium carbonate In tetraethoxy orthosilicate at 140℃; for 14 h;
实验步骤：将化合物2（6.2g，25mmol），碘苯（6.12g，30mmol），Cul（955mg，5.0mmol），CS2CO3（16.3g，50mmol）在TEOS（200ml）中的混合物脱气并吹扫 用氮气。 将所得混合物在140℃下搅拌14小时。 冷却至室温后，将残余物用EtOAc（200ml）和95％EtOH（200ml），NH 4 F-H 2 O在硅胶上稀释[50g，通过在水（1500ml）中加入NH 4 F（100g）预制备至二氧化硅。 加入凝胶（500g，100-200mesh）]，并将得到的混合物在室温下保持2小时，过滤固化的物质并用EtOAc洗涤。 将滤液蒸发至干，通过硅胶色谱法（石油醚/ EtOAc = 10/1）纯化残余物，得到黄色固体（3g，38％）。
参考文献：
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