4-(二甲基氨基)苯磺酸在医药、农药、染料等领域有应用，具体用途需结合具体领域进一步研究。
医药; 农药; 染料
路线1：
- 步骤: 将N,N-二甲基苯胺（2.5g，20mmol）和双三甲基甲硅烷基硫酸盐（5.0g，20mmol）的混合物在170℃下加热5小时；冷却至室温，过滤分离所得固体，用Et₂O洗涤；将固体溶解在H₂O中，真空浓缩得到标题化合物。
- 条件: 170℃，5小时；
- 收率: 100%（定量）；
- 参考文献: [1] Patent: US2010/256092, 2010, A1. Location in patent: Page/Page column 134 [2] European Journal of Medicinal Chemistry, 2001, vol. 36, #10, p. 809 - 828 [3] Synthesis, 1982, #4, p. 277 - 280 [4] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 37 [5] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 60 [6] Russian Journal of General Chemistry, 1996, vol. 66, #10, p. 1653 - 1655 [7] Chem. News J. Ind. Sci., 1896, vol. 73, p. 54 [8] Journal of the Indian Chemical Society, 1927, vol. 4, p. 323 [9] Chem. Zentralbl., 1928, vol. 99, #I, p. 491 [10] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1946, vol. 133, p. 20,30 [11] Journal of the Chemical Society, 1939, p. 1701 [12] Zhurnal Obshchei Khimii, 1933, vol. 3, p. 419,425 [13] Chem.Abstr., 1934, p. 1695 [14] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972, p. 2663 - 2666 [15] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972, p. 2666 - 2670 [16] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1972, p. 2666 - 2670 [17] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1977, vol. 26, p. 2174 - 2175 [18] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1977, vol. 26, p. 2340 - 2341 [19] Arzneimittel-Forschung/Drug Research, 1994, vol. 44, #4, p. 501 - 509 [20] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, #1, p. 349 - 352 [21] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, #1, p. 349 - 352
路线2：
- 步骤: 在冰浴条件下，向250 mL三颈圆底烧瓶中加入N,N-二甲基苯胺（20 g，165.29 mmol）的乙醚（40 mL）溶液；缓慢滴加硫酸（16.1 g，161.00 mmol）的乙醚（160 mL）溶液；反应完成后，通过旋转蒸发仪除去乙醚溶剂；将所得混合物在搅拌条件下，于170℃真空环境中反应4小时。
- 条件: 冰浴；170℃，真空，4小时；
- 收率: 32%；
- 参考文献: [1] Patent: US2010/256092, 2010, A1. Location in patent: Page/Page column 134 [2] European Journal of Medicinal Chemistry, 2001, vol. 36, #10, p. 809 - 828 [3] Synthesis, 1982, #4, p. 277 - 280 [4] Patent: US2008/318941, 2008, A1. Location in patent: Page/Page column 37 [5] Patent: US2008/200471, 2008, A1. Location in patent: Page/Page column 60
