3-碘-9-苯基咔唑是有机电致发光材料(OLED)的中间体，用于OLED生产工艺，可解决现有工艺复杂、收率低、成本高及污染严重的问题。
有机电致发光材料(OLED)
路线1：以N-苯基咔唑为原料合成3-碘-9-苯基咔唑
- 步骤: 将2.433 g（10 mmol）N-苯基咔唑（中间体化合物A）溶解于100 mL 80%乙酸溶液中，依次加入1.357 g（5.35 mmol）碘单质（I₂）和0.333 g（1.46 mmol）邻-正辛酸（H₅IO₆）；在氮气保护下，80℃搅拌反应2小时；反应完成后，用乙醚（50 mL）萃取三次，合并有机层，无水硫酸镁干燥，减压蒸发溶剂，硅胶柱色谱纯化，得到3.23 g 3-碘-9-苯基咔唑（中间体化合物B）。
- 条件: 反应温度80℃，反应时间2小时，氮气保护，溶剂为80%乙酸水溶液，萃取剂为乙醚，纯化方法为硅胶柱色谱。
- 收率: 87%。
- 参考文献: [1] Patent: EP1661888, 2006, A1. Location in patent: Page/Page column 11；[2] Patent: US2008/174237, 2008, A1. Location in patent: Page/Page column 13-14；[3] Patent: EP2149555, 2010, A1. Location in patent: Page/Page column 19；[4] Patent: KR101791161, 2017, B1. Location in patent: Paragraph 0116; 0123-0128；[5] Patent: EP2738166, 2014, A1. Location in patent: Paragraph 0162；[6] Patent: US8865322, 2014, B2. Location in patent: Page/Page column 25; 26; 38; 39；[7] Patent: KR2016/19744, 2016, A. Location in patent: Paragraph 0058; 0061; 0062; 0079; 0082; 0083；[8] Patent: KR2016/19745, 2016, A. Location in patent: Paragraph 0047; 0051-0052；[9] Patent: WO2006/70912, 2006, A1. Location in patent: Page/Page column 54；[10] Patent: WO2006/43647, 2006, A1. Location in patent: Page/Page column 56；[11] Patent: WO2006/70912, 2006, A1. Location in patent: Page/Page column 54; 55；[12] Patent: US2007/31701, 2007, A1；[13] Patent: EP2085382, 2009, A1. Location in patent: Page/Page column 38；[14] Patent: EP2100880, 2009, A1. Location in patent: Page/Page column 14-15；[15] Patent: EP2468725, 2012, A1. Location in patent: Page/Page column 119；[16] Patent: EP2484665, 2012, A1. Location in patent: Page/Page column 62；[17] Patent: EP2502908, 2012, A1. Location in patent: Page/Page column 41；[18] Patent: US2012/273766, 2012, A1. Location in patent: Page/Page column 70；[19] Patent: EP2527334, 2012, A1. Location in patent: Page/Page column 89；[20] Patent: EP2617712, 2013, A1. Location in patent: Paragraph 0157；[21] Patent: EP2690093, 2014, A1. Location in patent: Paragraph 0130
