941685-26-3 4-氯-7-((2-(三甲基甲硅烷基)乙氧基)甲基)-7H-吡咯并[2,3-d]嘧啶

干冰运输，危险性质非危险化学品，危险等级为IRRITANT（刺激性）

作为有机合成中间体和医药中间体，主要用于实验室研发过程和化工生产过程中。

医药中间体; 有机合成中间体

合成路线 1（1. 合成：941685-26-3）

• 步骤：在用冰盐浴冷却下，将氢化钠（340mg，60％）分两部分加入到4-氯吡咯并嘧啶（3a）（1.0g，6.5mmol）的DMF（15mL）溶液中，同时保持温度为0℃。反应物不高于10℃，在氮气氛下保护反应1小时。通过注射器缓慢加入SEMCI（1.4g，8.5mmol），同时保持温度不高于10℃。将反应温热至室温，搅拌过夜。将反应用水淬灭，用EA萃取，经无水硫酸钠干燥，浓缩有机相，并通过制备型快速色谱法（PE：EA = 19：1）纯化，得到4-氯-7-((2-(三甲基甲硅烷基)乙氧基)甲基)-7H-吡咯并[2,3-d]嘧啶（3b）（1.834g，油状产物）。
• 条件：Stage #1: With sodium hydride In N,N-dimethyl-formamide; mineral oil at 10℃; for 1 h; Cooling with ice; Inert atmosphere；Stage #2: at 10 - 20℃。
• 产率：97%。
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