化学合成。
医药; 农药
合成路线 1（1. 合成：914358-73-9）
产率：90%
合成条件：With hydrogenchloride; iron In methanol; water for 2 h; Reflux
实验步骤：在40℃下，向工业甲基化酒精（330mL）中的5-溴-2-甲基-3-硝基吡啶（13.8g，63.9mmol）溶液中加入铁粉（20g）（分批以避免结块），然后 用浓盐酸水溶液（5mL）洗脱。 将深棕色混合物在回流下剧烈搅拌2小时，然后冷却并通过Celite过滤。 （用1L工业甲基化酒精洗涤）。 然后真空除去溶剂，将残余物溶于乙酸乙酯（200mL）中，用饱和碳酸氢钠水溶液（200mL）洗涤，用硫酸镁干燥，真空除去溶剂，得到5-溴-2 - 甲基吡啶-3-胺，为橙色固体（10.7g，90％）。 1HNMR（400MHz，CDCl3，δ）：7.91（s，1H），7.00（s，1H），3.75（br.s。，2H），2.25（s，3H）。
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