56059-30-4 2,4-二氧代-5-氟-3,4-二氢-1(2H)-嘧啶乙酸

海关编码:2933599590

作为医药中间体或活性成分，用于相关药物研发与生产。

医药

合成路线 1（1. 合成：56059-30-4）

产率：60% 合成条件：Stage #1: With potassium hydroxide In water at 100℃; for 1.33 h; Stage #2: at 60℃; for 6 h; 实验步骤：FUAC的编写方法已在文献[21]中公布，并作了一些修改。 将KOH（0.60g，10.6mmol，10mL）的水溶液加入到5-FU（1g，5.2mmol）中。 将反应混合物在100℃下搅拌80分钟。 然后在60℃的油浴中逐渐加入氯乙酸（84mL，0.5g，5.2mmol）溶液并搅拌6小时。 通过加入稀释的HCl以达到pH = 2并冷却至4℃12小时酸化结果。 通过过滤收集形成的沉淀，并将其溶解在饱和KHCO 3溶液中。 再次，将溶液用稀HCl酸化至pH = 2，得到FUAC的针状晶体（0.82g，60％收率）。 参考文献：

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