40971-36-6 1,2,3,4-四氢-2-喹啉甲醇

中文名称: 1,2,3,4-四氢-2-喹啉甲醇
英文名称: (1,2,3,4-Tetrahydroquinolin-2-yl)methanol
CAS号

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名称和标识

中文名: 1,2,3,4-四氢-2-喹啉甲醇
英文名: (1,2,3,4-Tetrahydroquinolin-2-yl)methanol
CAS号: 40971-36-6
分子式: C10H13NO
分子量: 163.22
中文别名: 1,2,3,4-四氢-2-喹啉基甲醇; 1,2,3,4-四氢喹啉-2-甲醇; (1,2,3,4-四氢喹啉-2-基)甲醇
英文别名: 1,2,3,4-Tetrahydro-2-quinolinemethanol; 2-Hydroxymethyl-1,2,3,4-tetrahydroquinoline; (2S)-1,2,3,4-Tetrahydro-2-quinolinylMethanol; 2-Quinolinemethanol, 1,2,3,4-tetrahydro-; 1,2,3,4-tetrahydroquinolin-2-ylmethanol; 1,2,3,4-Tetrahydro-2-quinolinylmethanol; 2-hydroxymethyltetrahydroquinoline; (1,2,3,4-tetrahydro-quinolin-2-yl)-methanol; 2-Quinolinemethanol,1,2,3,4-tetrahydro

物化属性

LogP: 1.13
Num. H-bond acceptors: 1.0
Num. H-bond donors: 2.0
Num. heavy atoms: 12
Num. rotatable bonds: 1

安全信息

安全说明

危险性质：非危险化学品

生产及用途

用途与制备

化学合成。

化学合成

合成路线 1（1. 合成：40971-36-6）

产率：50% 合成条件：Stage #1: With lithium aluminium tetrahydride In tetrahydrofuran at 0 - 25℃; for 5 h; Heating / reflux Stage #2: With water; sodium sulfate In tetrahydrofuran 实验步骤：在0℃下，将1,2,3,4-四氢喹啉-2-羧酸乙酯（25mmol）的四氢呋喃（5ml / mol）滴加到氢化铝锂（2当量）的四氢呋喃悬浮液中。（50毫升）。将反应混合物在25℃下搅拌1小时，然后回流4小时。通过薄层色谱监测反应进程。向反应混合物中加入饱和硫酸钠溶液，然后将混合物用硅藻土过滤并用乙酸乙酯洗涤。将滤液真空浓缩，并将粗产物通过柱色谱（3：7乙酸乙酯/己烷）纯化。产量：50％ 参考文献：

[1] Patent: US2008/153843, 2008, A1. Location in patent: Page/Page column 77 [2] Patent: US2008/249128, 2008, A1. Location in patent: Page/Page column 42 [3] Patent: US2008/306084, 2008, A1. Location in patent: Page/Page column 56 [4] Patent: WO2009/90055, 2009, A1. Location in patent: Page/Page column 90 [5] Patent: US2009/253669, 2009, A1. Location in patent: Page/Page column 44-45 [6] Patent: US2009/264400, 2009, A1. Location in patent: Page/Page column 29 [7] Patent: US2009/264407, 2009, A1. Location in patent: Page/Page column 24-25 [8] Patent: WO2009/109364, 2009, A1. Location in patent: Page/Page column 96