- 急性毒性
口服-大鼠 LD:>500 毫克/公斤;静脉-小鼠 LD50: 100 毫克/公斤
- 可燃性危险特性
热分解排出有毒溴化物和氮氧化物烟雾
- 储运特性
库房通风低温干燥
- 灭火剂
水,干粉、干砂、二氧化碳、泡沫、1211灭火剂
医药; 农药
合成路线 1（1. 合成：13296-94-1）
产率：99%
合成条件：With pyrrolidone hydrotribromide In methanol; dichloromethane at 20℃; for 0.50 h;
实验步骤：在室温下，用PHT（6.30g，12.7mmol，1.1当量）处理4-硝基苯胺（1.60g，11.6mmol，1当量）在DCM（40mL）和MeOH（20mL）中的溶液。 方式。 然后继续搅拌0.5小时。 将混合物用Et 2 O（50mL）稀释，先用饱和Na 2 S 2 O 3水溶液（40mL）洗涤，然后用盐水（40mL）洗涤。 将有机萃取物用MgSO 4干燥，然后过滤并减压除去溶剂。 通过快速柱色谱法（c-Hex-EtOAc; 2：1）纯化，得到S8（2.50g，99％），为黄色固体。
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合成路线 2（3. 合成：13296-94-1）
产率：65.6%
合成条件：With bromine In water; acetic acid
实验步骤：实施例I 2-溴-4-硝基苯胺将100g（0.724mol）对硝基苯胺在40℃下缓慢加入1550ml冰醋酸中。将溶液冷却至20℃后，37.4ml（116.65g， 在1小时内逐滴加入0.730mol）溴，然后将溶液再搅拌45分钟。 通过抽滤收集反应过程中形成的沉淀，并与2500ml 10％亚硫酸氢钠水溶液一起搅拌16小时; 通过抽滤再次收集并用2500ml水洗涤。 将固体风干24小时。 将粗物质（139g）从65％甲醇中重结晶两次，得到103g（65.6％）黄色结晶固体，其在101℃-102℃下熔化。 IR（KBr）3500,3400,1125cm -1（NH 2）; 1500,1325（NO2）。。计算。 C 6 H 5 N 2 O 2 Br：C，33.18; H，2.30; N，12.90。 实测值：C，33.26; H，2.28; N，12.92。
参考文献：
- [1] Patent: US754, 1990, H1
