化学合成,医药雷诺嗪、心乐宁(莫普洛尔)的中间体;生命科学。
医药
合成路线 1(1. 合成:2210-74-4)
产率:80%
合成条件:With sodium hydroxide In water
实验步骤:向R.B Flask中加入2.5L水,加入80g NaOH并搅拌溶解。 加入500克愈创木酚,1.12千克环氧氯丙烷,在25-35℃搅拌5-6小时。 分离有机层。 向环氧氯丙烷层中加入溶解在2.5L水中的160克NaOH,并在25-30℃下搅拌3-4小时。 分离有机层并用溶解在1.5L水中的150g NaOH洗涤。 通过在90℃真空(600-700mmHg)下蒸馏产物层回收过量的表氯醇,得到65 0-680克油。 向该cmde油中加入3.0L异丙醇并冷却至0℃并过滤产物,得到1-(2-甲氧基苯氧基)-2,3-环氧丙烷(3)。产率:80%; 纯度> 98%。
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