化学合成。
有机合成; 医药中间体
合成路线 1（1. 合成：850462-64-5）
产率：45.1%
合成条件：at -110 - -15℃; for 4.50 h;
实验步骤：引入116ml硫酸并在-15℃下与14.70g（95.37mmol）5-氟-2-甲基苯甲酸分批混合。 向该混合物中滴加硝酸（4.79ml发烟硝酸和21.8ml浓硫酸）的混合物，特别是在-15至-110℃下90分钟。 再搅拌3小时后，将反应混合物倒入冰水中并剧烈搅拌约半小时。 抽吸沉淀的结晶，用水洗涤中性并干燥。 产率为8.56g（45.1％）各种区域异构体和副产物的混合物。 因此该混合物用于下一阶段（酯化）并在该阶段中纯化。
参考文献：
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