化学合成。
化学合成; 精细化工中间体
合成路线 1（1. 合成：1074-24-4）
产率：96.5%
合成条件：With bromine; iodine In dichloromethane; water at 12℃; for 18 h;
实验步骤：将圆筒在二氯甲烷（50mL）中称重并置于150mL双颈圆底烧瓶中。使用移液管精确测量二氯甲烷中对二甲苯（16.96g，0.16mol，19.8mL）的量。将碘（0.1g，0.8mmol）加入混合物中，在烧瓶的一个开口处安装空气冷凝管并连接尾气回收装置。烧瓶的另一个开口装有恒压进料器。并使用用移液管准确取出液体溴（18mL）并将其转移到恒压进料器中。在液体溴的顶部加一层水（约0.3-0.5cm）以防止液体溴蒸发。然后放置一个塞子在强力搅拌和黑暗条件下，将反应体系的温度控制在12℃。将液体溴滴加到混合物中（40至50分钟）。注意不要滴下上层水溶液。分层进入反应溶液。反应18h。反应完成后，加入40mL w（KOH）= 25％水溶液并剧烈搅拌30分钟。将反应混合物转移至分液漏斗中。分离下层有机相并用水洗涤（2×50）。用无水CaCl2干燥，过滤，减压除去溶剂，残余物用乙醇（2×300mL）重结晶，得到白色针状物。产率96.5％（40.44g），
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