化学合成。
化学合成
合成路线 1（1. 合成：304873-65-2）
产率：84%
合成条件：With sodium hydrogencarbonate In dichloromethane; water at 0℃; for 1 h;
实验步骤：向步骤2的产物（19.15g，85.5 [MMOL]]的[CH 2 Cl 2]（640ml）溶液中加入饱和的[NAHC03]水溶液（8.62g，103 [MMOL]]和NaBr（444mg） ，4.3 [MMOL]。]将反应混合物冷却至0 [℃]，并引入TEMPO（140mg，0.90 [MMOL]]。 在剧烈搅拌下，在40分钟内分批加入市售漂白溶液（122 [ML，] 0.7 [M，] 85.4 [MMOL]]（5.21％NaOCl）。 在0 [℃]下再过20分钟后，将反应混合物用饱和Na 2 S 2 O 3水溶液淬灭，并使其温热至23 [℃]。用水稀释并用CH 2 Cl 2萃取，然后浓缩并进行快速色谱（洗脱液：30％） [己烷-CH 2 Cl 2]至0-2％[ACETONE-CH 2 Cl 2]]，得到15.97g（71.9 [MMOL]; 84％收率）醛，为灰白色固体。
参考文献：
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