617-55-0 (S)-2-羟基琥珀酸二甲酯

运输信息：冰袋运输。危险描述：危险性质为否，危险品属性为冷藏品。

化学合成。

化学合成

路线1：以L-苹果酸和甲醇为原料的酯化反应

• 步骤：在冰水浴中，将亚硫酰氯（117g，0.98mol）加入到L-苹果酸（59.9g，0.45mol）的甲醇（400mL）溶液中；添加完成后，将反应混合物在室温（25℃）下搅拌过夜；用TLC（EtOAc：MeOH = 10：1）监测反应；真空除去溶剂；加入饱和NaHCO₃溶液（200mL），水相用EtOAc（3×150mL）萃取；合并的有机相依次用水（3×80mL）、盐水（3×80mL）洗涤，Na₂SO₄干燥，减压除去溶剂，得到浅黄色油状物产物。
• 条件：冰水浴冷却下加料，室温（25℃）反应过夜。
• 收率：98%（71.5g，0.44mol）
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