生命科学。
生命科学
合成路线 1（1. 合成：34079-31-7）
产率：49%
合成条件：With pyridine; di- tert -butyl dicarbonate; ammonium bicarbonate In 1,4-dioxane at 20℃;
实验步骤：在1，4-中开始1 - {[（苯基甲基）氧基]羰基} -L-脯氨酸（8.0g，32.09mmol），吡啶（1.5mL），（BoC）2O（9.1g，41.72mmol）的溶液 在室温下加入二恶烷（40mL），加入碳酸氢铵（3.2g，40.43mmol）。 在室温下搅拌过夜后，将反应混合物用EtOAc（100mL）处理，然后将混合物用水（50mL）洗涤，接着用5％H 2 SO 4洗涤。收集有机层，干燥（Na 2 SO 4），过滤。 通过真空蒸发除去挥发物。 将得到的澄清油状物用乙醚研磨。 过滤沉淀物，并在真空下进一步干燥，得到标题化合物，为白色固体（3.9g，49％）。 MH + 249。
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