化学合成。
医药化工合成中间体
合成路线 1（1. 合成：459-46-1）
产率：100%
合成条件：With phosphorus tribromide In benzene at 20℃;
实验步骤：通用方法：在无水苯（15mL）和三溴化磷（0.5mL）中的苄醇（1mmol）并在室温下搅拌，以定量收率得到各自的苄基溴，通常进行后处理。
参考文献：
- [1] Journal of Steroid Biochemistry and Molecular Biology, 2013, vol. 137, p. 332 - 344 [2] Bulletin of the Chemical Society of Ethiopia, 2012, vol. 26, # 2, p. 305 - 309 [3] Tetrahedron Letters, 2016, vol. 57, # 22, p. 2430 - 2433 [4] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 8, p. 2989 - 3002 [5] Chem, 2018, vol. 4, # 1, p. 124 - 137 [6] Nippon Kagaku Zasshi, 1958, vol. 79, p. 1428,1430 [7] Chem.Abstr., 1960, p. 5518 [8] Chemical Communications, 2014, vol. 50, # 28, p. 3692 - 3694 [9] Organic Letters, 2014, vol. 16, # 2, p. 484 - 487 [10] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 13, p. 3465 - 3477 [11] Bioorganic Chemistry, 2019, vol. 83, p. 535 - 548 [12] Organic and Biomolecular Chemistry, 2015, vol. 13, # 17, p. 4879 - 4895 [13] Organic and Biomolecular Chemistry, 2015, vol. 13, # 40, p. 10136 - 10149 [14] Journal of the American Chemical Society, 2015, vol. 137, # 30, p. 9567 - 9570 [15] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 2, p. 561 - 569 [16] Advanced Synthesis and Catalysis, 2016, vol. 358, # 11, p. 1731 - 1735 [17] Chemical Biology and Drug Design, 2016, p. 97 - 109 [18] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 36 - 51 [19] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 13, p. 3285 - 3297 [20] European Journal of Medicinal Chemistry, 2017, vol. 127, p. 100 - 114 [21] Journal of Heterocyclic Chemistry, 2017, vol. 54, # 1, p. 413 - 421 [22] Chinese Chemical Letters, 2016, vol. 27, # 2, p. 295 - 301
