化学合成。
医药化工合成中间体
合成路线 1（1. 合成：459-46-1）
产率：100%
合成条件：With phosphorus tribromide In benzene at 20℃;
实验步骤：通用方法：在无水苯（15mL）和三溴化磷（0.5mL）中的苄醇（1mmol）并在室温下搅拌，以定量收率得到各自的苄基溴，通常进行后处理。
参考文献：
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合成路线 2（2. 合成：459-46-1）
产率：95%
合成条件：With N-Bromosuccinimide; dibenzoyl peroxide In chloroform at 70℃; for 6 h; Large scale
实验步骤：取110kg 4-氟甲苯，溶于500kg氯仿中，加入180kg NBS，加入BPO12kg，反应加热至70℃，回流6小时。 反应结束后，冷却至室温。过滤后，将滤液减压回收氯仿，减压蒸馏除去残渣，得到177kg淡黄色液体，收率95％。
参考文献：
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