化学合成。
化学合成
合成路线 1（1. 合成：2674-34-2）
产率：85%
合成条件：With bromine In chloroform at 0℃; for 3 h;
实验步骤：实施例2：2,5-二溴-1,4-二甲氧基苯（2）的制备; 在1升圆底烧瓶中，将溴（35.2g，220mmol）的氯仿（50ml）溶液滴加到1,4-二甲氧基苯（13.8g，100mmol）的氯仿溶液中。 （00毫升）（400毫升）。 搅拌3小时后，加入100ml饱和Na 2 CO 3溶液。 将有机层用水，盐水洗涤，并经硫酸钠干燥。 在旋转蒸发器上除去溶剂，残余物用乙醇重结晶，得到纯的2,5-二溴-1,4-二甲氧基苯（25.8g，85％）。 1HNMR（CDCl 3）57.128（s，2H），3.873（s，6H）。
参考文献：
- [1] Tetrahedron, 1999, vol. 55, # 36, p. 11127 - 11142 [2] Tetrahedron Letters, 1998, vol. 39, # 35, p. 6349 - 6350 [3] Organic Process Research and Development, 2016, vol. 20, # 2, p. 284 - 296 [4] Journal of the American Chemical Society, 2003, vol. 125, # 37, p. 11241 - 11248 [5] Journal of Materials Chemistry A, 2017, vol. 5, # 44, p. 22933 - 22938 [6] Journal of Materials Chemistry A, 2018, vol. 6, # 2, p. 374 - 382 [7] Synlett, 2005, # 17, p. 2664 - 2666 [8] Tetrahedron, 1997, vol. 53, # 30, p. 10357 - 10400 [9] New Journal of Chemistry, 2014, vol. 38, # 6, p. 2229 - 2232 [10] Journal of Organic Chemistry, 1998, vol. 63, # 11, p. 3764 - 3768 [11] Patent: WO2006/93467, 2006, A1. Location in patent: Page/Page column 26 [12] Synthetic Communications, 2001, vol. 31, # 13, p. 2021 - 2027 [13] Patent: CN106397468, 2017, A. Location in patent: Paragraph 0012; 0018; 0022 [14] Synthetic Communications, 1998, vol. 28, # 3, p. 499 - 505 [15] Chemical Communications, 2016, vol. 52, # 74, p. 11088 - 11091 [16] Tetrahedron, 2001, vol. 57, # 24, p. 5109 - 5121 [17] Journal of Organic Chemistry, 1980, vol. 45, # 3, p. 378 - 384 [18] Tetrahedron, 2015, vol. 71, # 2, p. 283 - 292 [19] Journal of Organic Chemistry, 2011, vol. 76, # 20, p. 8501 - 8507 [20] Patent: WO2010/129049, 2010, A1. Location in patent: Page/Page column 111; 113 [21] Tetrahedron Letters, 2014, vol. 55, # 24, p. 3511 - 3515 [22] Synthetic Communications, 1998, vol. 28, # 11, p. 2087 - 2095 [23] Austral. J. scient. Res., 1949, vol. 2, p. 595,599 [24] Chemische Berichte, 1878, vol. 11, p. 1036 [25] Journal of the Chemical Society, 1925, vol. 127, p. 2003 [26] Chemische Berichte, 1878, vol. 11, p. 1036 [27] Synthetic Communications, 2002, vol. 32, # 20, p. 3233 - 3239 [28] Macromolecules, 2002, vol. 35, # 13, p. 4975 - 4982 [29] Organic Letters, 2001, vol. 3, # 3, p. 445 - 447 [30] Canadian Journal of Chemistry, 2008, vol. 86, # 10, p. 976 - 981 [31] Polymer, 2010, vol. 51, # 3, p. 632 - 638 [32] Angewandte Chemie - International Edition, 2018, vol. 57, # 35, p. 11310 - 11315 [33] Angew. Chem., 2018, vol. 130, p. 11480 - 11485,6
