作为医药合成中间体，用于相关药物分子的制备。
医药
合成路线 1（1. 合成：141403-49-8）
产率：78%
合成条件：With triethylamine In dichloromethane at 0 - 20℃;
实验步骤：将S-Ztoophenylalaninol（1g，3.98mmol）溶解在DCM中。 在0℃下向该溶液中缓慢加入三乙胺和对甲苯磺酰氯。 然后将反应物在室温下搅拌过夜。 反应完成后，蒸发DCM，并使用柱色谱法纯化粗制反应混合物。 得到纯产物13a，为白色蓬松固体，收率78％（1.26g）。 得到纯产物13b，为白色固体，收率81％
参考文献：
- [1] Tetrahedron Letters, 1995, vol. 36, # 14, p. 2505 - 2508 [2] Tetrahedron, 1997, vol. 53, # 13, p. 4769 - 4778 [3] European Journal of Medicinal Chemistry, 1989, vol. 24, # 5, p. 503 - 510 [4] Heterocycles, 2009, vol. 77, # 2, p. 865 - 872 [5] Organic and Biomolecular Chemistry, 2014, vol. 12, # 23, p. 3976 - 3985 [6] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988, p. 1645 - 1652 [7] Journal of Medicinal Chemistry, 2016, vol. 59, # 9, p. 4210 - 4220 [8] Patent: WO2017/44742, 2017, A1. Location in patent: Page/Page column 42; 43 [9] Journal of Organic Chemistry, 2001, vol. 66, # 14, p. 4904 - 4914 [10] European Journal of Medicinal Chemistry, 1993, vol. 28, # 1, p. 47 - 61 [11] Patent: WO2008/22345, 2008, A2. Location in patent: Page/Page column 47 [12] Patent: WO2009/105782, 2009, A1. Location in patent: Page/Page column 44 [13] Patent: US2015/284352, 2015, A1. Location in patent: Paragraph 0249; 0250 [14] Chemistry Letters, 1992, # 12, p. 2409 - 2412 [15] Journal of Medicinal Chemistry, 1992, vol. 35, # 7, p. 1259 - 1266 [16] Journal of Organic Chemistry, 1997, vol. 62, # 20, p. 6754 - 6759 [17] Journal of Organic Chemistry, 1998, vol. 63, # 22, p. 7764 - 7769 [18] Angewandte Chemie - International Edition, 2000, vol. 39, # 15, p. 2752 - 2754 [19] Tetrahedron, 2007, vol. 63, # 39, p. 9758 - 9763 [20] Synlett, 2007, # 12, p. 1893 - 1896 [21] Journal of Peptide Science, 2011, vol. 17, # 7, p. 527 - 532 [22] Patent: WO2014/52699, 2014, A1. Location in patent: Page/Page column 222-223 [23] Tetrahedron Asymmetry, 2015, vol. 26, # 1, p. 67 - 72 [24] Organometallics, 2014, vol. 33, # 22, p. 6452 - 6465 [25] RSC Advances, 2017, vol. 7, # 26, p. 15742 - 15746
