30992-63-3 1-(5-(苄氧基)-2-羟基苯基)乙酮

运输方式为冰袋运输，危险性质非危险化学品，海关编码为2914390090

作为中间体用于合成目标二酯（1-8），在医药领域有应用。

医药

路线1：

• 步骤：首先用苄基保护OH官能团，与O-烷基化反应条件相同，以95%收率得到苯乙酮衍生物（1-6）；然后苯乙酮衍生物（1-6）经Vilsmeier-Haack反应（70%收率）得到产物（1-7）；最后产物（1-7）与丙二酸二乙酯进行Knoevenagel缩合（94%收率）得到目标二酯（1-8）。
• 条件：With 18-crown-6 ether; potassium carbonate; potassium iodide In toluene at 115℃; for 14 h；With potassium iodide In acetone for 6 h; Reflux
• 收率：95%（O-烷基化）；70%（Vilsmeier-Haack反应）；94%（Knoevenagel缩合）；总产率42%（中间体1-7）
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