用于医药中间体合成;作为农药合成原料;在有机合成中作为溴代甲基化试剂。
医药; 农药
路线1:
- 原料:4'-甲基苯乙酮(51229-51-7)、N-溴代琥珀酰亚胺(NBS)、偶氮二异丁腈(AIBN)、乙腈、二氯甲烷、盐酸、碳酸氢钠、盐水、无水硫酸钠、石油醚
- 步骤:在干燥圆底烧瓶中,将4ml 4'-甲基苯乙酮溶于30ml无水乙腈,氩气保护下加入5.9g NBS和500μl AIBN,95℃回流8h;冷却后减压干燥溶剂,残余物溶于40ml二氯甲烷,依次用2M盐酸、饱和碳酸氢钠、饱和盐水洗涤,无水硫酸钠干燥,减压干燥溶剂后石油醚重结晶,硅胶柱层析(酯=30:1)得产物
- 条件:氩气保护;95℃回流8h;硅胶柱层析(酯=30:1)
- 收率:95%
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