6941-75-9 5-溴异吲哚-1,3-二酮

运输信息：常温运输。危险描述：非危险化学品，海关编码2933998090

化学合成；黄色至浅黄色粉末

化学合成

路线1：

• 步骤: 将中间体I-54（6.6g，0.30mol，1.0当量）和甲酰胺（10mL，2.4mol，8.0当量）的混合物在200℃下搅拌2小时并倒入冰水混合物中，过滤收集晶体并真空干燥，得到中间体I-55（7.0g，99％）。
• 条件: 200℃；2小时
• 收率: 99%
• 参考文献: [1] Patent: US2010/204214, 2010, A1. Location in patent: Page/Page column 109 [2] Patent: JP5906522, 2016, B2. Location in patent: Paragraph 0058; 0059 [3] Chemistry of Materials, 2010, vol. 22, # 18, p. 5258 - 5270 [4] Molecules, 2010, vol. 15, # 8, p. 5561 - 5580 [5] Patent: WO2014/89324, 2014, A1. Location in patent: Paragraph 0234 [6] Patent: CN104016979, 2017, B. Location in patent: Paragraph 0596; 0597; 0598 [7] Journal of Medicinal Chemistry, 2017, vol. 60, # 3, p. 1142 - 1150 [8] Patent: WO2018/95260, 2018, A1. Location in patent: Paragraph 058; 061; 0116 [9] Organic Letters, 2013, vol. 15, # 14, p. 3738 - 3741 [10] Patent: US2014/302987, 2014, A1. Location in patent: Paragraph 0200-0201 [11] Journal of Materials Chemistry C, 2017, vol. 5, # 34, p. 8723 - 8733 [12] Patent: CN107082769, 2017, A. Location in patent: Paragraph 0017; 0018 [13] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 21, p. 5738 - 5746 [14] Patent: WO2008/44029, 2008, A1. Location in patent: Page/Page column 214 [15] Patent: WO2008/44041, 2008, A1. Location in patent: Page/Page column 236 [16] Patent: WO2008/44045, 2008, A1. Location in patent: Page/Page column 288 [17] Patent: WO2008/44054, 2008, A2. Location in patent: Page/Page column 132-133 [18] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 14, p. 4159 - 4162 [19] Patent: US2010/152184, 2010, A1. Location in patent: Page/Page column 80