生命科学。
生命科学
合成路线 1（1. 合成：2899-37-8）
产率：75%
合成条件：With sodium hydroxide; chloro-trimethyl-silane; lithium borohydride In methanol
实验步骤：参考实施例1-46（2S）-2-氨基-4-甲基硫代丁醇（参考化合物No.1-46）的合成：将38ml（300mmol）氯三甲基硅烷滴加到200ml含3.3g的无水四氢呋喃悬浮液中在冰冷条件下（150mmol）硼氢化锂。将反应混合物搅拌30分钟。向反应混合物中逐渐加入7.5g（50mmol）L-甲硫氨酸，然后在室温下搅拌过夜。在冰冷条件下将甲醇进一步加入到反应混合物中，直到氢气的释放停止。在减压下从反应混合物中蒸馏出溶剂。向所得残余物中加入10％氢氧化钠溶液，然后用氯仿萃取两次。将得到的氯仿萃取层用无水硫酸钠干燥后，减压蒸馏除去溶剂，得到5.12g标题化合物No.1-46，收率75％。
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