368-63-8 1-[3,5-双(三氟甲基)苯基]乙醇

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合成路线 3（3. 合成：368-63-8）

产率：99.2% 合成条件：With lithium hydroxide In methanol for 10 h; Reflux 实验步骤：R-3,5-双三氟甲基苯乙酸乙酯的水解将步骤1中得到的8.51g淡黄色油状液体加入100ml甲醇1N LiOH中，按体积比1：1制备混合溶液，加热回流反应， 10小时，R-3,5-双三氟甲基苯乙醇乙酸酯的检测消失。浓缩反应溶液，蒸馏除去甲醇，残余溶液用二氯甲烷萃取，干燥，浓缩，得到7.95g淡黄色油状液体。 。从步骤2中得到的7.95g淡黄色油状液体中得到体积比为10：1的正己烷和乙酸乙酯的混合物。通过凝胶过滤进一步纯化该溶液。最终得到的4.70G R-3,5 -bisbiphenylmethylethanol，经测试，最终产品范围的R-3,5B（三氟甲基）苯基乙醇的含量为99.2％。 值 参考文献：

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