30363-03-2 2,4,6-三(4-溴苯基)-1,3,5-三嗪

危险性质：非危险化学品

化学合成。

化学合成

合成路线 1（1. 合成：30363-03-2）

产率：93.6% 合成条件：at 0 - 20℃; for 12.50 h; Inert atmosphere; Cooling with ice 实验步骤：（1）2,4,6-三（4-溴苯基）-1,3,5-三嗪的合成向氮气置换的二颈烧瓶中加入三氟甲磺酸（66.6mmol，9.99g）， 在冰浴上冷却（0至5℃）。 向其中加入4-溴苯甲腈（19.6mmol，3.57g），并将混合物搅拌30分钟。 然后，将混合物在室温下搅拌12小时。 将水加入混合物中，然后用NaOH中和，然后用氯仿和丙酮（50/50）的混合溶剂洗涤，萃取有机层。 有机层用无水硫酸镁脱水，蒸馏除去溶剂，得到2,4,6-三（4-溴苯基）-1,3,5-三嗪作为目标产物（产量：3.34g， 产率：93.6％）。 参考文献：

• [1] Dalton Transactions, 2015, vol. 44, # 8, p. 3720 - 3723 [2] Chemistry of Materials, 2013, vol. 25, # 18, p. 3766 - 3771 [3] Patent: EP2808323, 2014, A1. Location in patent: Paragraph 0096-0097 [4] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2009, vol. 48, # 12, p. 1766 - 1770 [5] Chemistry - A European Journal, 2018, [6] Chemistry Letters, 1999, # 7, p. 545 - 546 [7] Dyes and Pigments, 2017, vol. 145, p. 43 - 53 [8] Patent: CN107686467, 2018, A. Location in patent: Paragraph 0023; 0030; 0031 [9] Patent: CN108239072, 2018, A. Location in patent: Paragraph 0144; 0145 [10] Journal of Materials Chemistry, 2002, vol. 12, # 2, p. 206 - 212 [11] Journal of the Chilean Chemical Society, 2015, vol. 60, # 2, p. 2971 - 2974 [12] Russian Journal of Organic Chemistry, 1996, vol. 32, # 10, p. 1447 - 1470 [13] Chemical Communications, 2007, # 35, p. 3637 - 3639 [14] Journal of Materials Chemistry C, 2015, vol. 3, # 19, p. 4890 - 4902 [15] CrystEngComm, 2012, vol. 14, # 3, p. 768 - 770 [16] Chemistry - An Asian Journal, 2016, vol. 11, # 18, p. 2555 - 2563 [17] Anales de la Asociacion Quimica Argentina (1921-2001), 1946, vol. 34, p. 146,149, 151 [18] Tetrahedron Letters, 2001, vol. 42, # 24, p. 3993 - 3996 [19] Molecular Crystals and Liquid Crystals Science and Technology Section A: Molecular Crystals and Liquid Crystals, 2002, vol. 378, p. 13 - 21 [20] Chemistry Letters, 2004, vol. 33, # 10, p. 1244 - 1245 [21] RSC Advances, 2013, vol. 3, # 9, p. 2889 - 2892 [22] Dyes and Pigments, 2013, vol. 97, # 3, p. 412 - 422 [23] Journal of Materials Chemistry A, 2015, vol. 3, # 2, p. 878 - 885 [24] Patent: CN106905366, 2017, A. Location in patent: Paragraph 0089 [25] Chemistry - A European Journal, 2017, vol. 23, # 53, p. 13023 - 13027 [26] Chemistry - A European Journal, 2018, vol. 24, # 46, p. 11916 - 11921 [27] Advanced Materials, 2017, vol. 29, # 40, [28] Journal of the American Chemical Society, 2018, vol. 140, # 15, p. 5248 - 5256 [29] Journal of Materials Chemistry A, 2018, vol. 6, # 40, p. 19532 - 19541 [30] Angewandte Chemie - International Edition, 2018, vol. 57, # 43, p. 14188 - 14192 [31] Angew. Chem., 2018, vol. 130, # 43, p. 14384 - 14388,5