化学合成。
医药; 香料; 染料
合成路线 1（1. 合成：2316-64-5）
产率：84%
合成条件：With sodium tetrahydroborate In ethanol at 0 - 20℃; for 18 h; Schlenk technique; Inert atmosphere
实验步骤：根据文献使用改进的合成方法制备化合物：在0℃下，将5-溴-2-羟基苯甲醛（10.1g，50mmol）溶解在250mL乙醇中。 将NaBH 4（1.88g，50mmol）分批（0.3g）加入到搅拌的溶液中。 将混合物在室温下搅拌18小时。 在减压（10 2毫巴）下除去乙醇后，将得到的浅黄色固体溶于200mL饱和NH 4 Cl水溶液中。 将粗产物用乙醚（三次80mL）萃取。 将有机相用盐水洗涤（三次，20mL）并用MgSO 4干燥2小时。 通过过滤除去MgSO 4并在减压（10 2 mbar）下过量溶剂后，通过快速色谱法用二氧化硅（洗脱液：正己烷/乙酸乙酯 - 体积比为8/2）纯化产物，蒸发后得到无色固体。 溶剂（8.52克，84％）;
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