6425-46-3 4-(4-硝基苄基)吗啉

中文名称: 4-(4-硝基苄基)吗啉
英文名称: 4-(4-Nitrobenzyl)morpholine
CAS号

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名称和标识

中文名: 4-(4-硝基苄基)吗啉
英文名: 4-(4-Nitrobenzyl)morpholine
CAS号: 6425-46-3
分子式: C11H14N2O3
分子量: 222.24
中文别名: 4-[(4-硝基苯基)甲基]吗啉; 4-(4-硝基苄基)吗啡啉
英文别名: 4-[(4-nitrophenyl)Methyl]Morpholine; Morpholine, 4-[(4-nitrophenyl)Methyl]-; 4-(N-Morpholinomethyl)-1-nitrobenzene; 4-(morpholino-methyl)-nitrobenzene; 4-(4-Nitro-benzyl)-morpholine

物化属性

pKa: 5.82±0.10 (Predicted)
储存条件: 密封储存，储存于阴凉、干燥的库房，远离腐蚀区
外观: 黄色或橙色固体
密度: 1.2±0.1 g/cm³
折射率: 1.578
拓扑分子极性表面积

安全信息

安全说明

海关编码:2933399990

生产及用途

用途与制备

4-(4-硝基苄基)吗啉主要作为医药中间体，用于多种药物的合成研究，在相关专利和学术文献中被广泛提及。

医药

路线1：

步骤: 向反应烧瓶中加入对硝基苄基溴（72.084g）和二氯甲烷（470mL，经分子筛干燥），搅拌至完全溶解；加入无水碳酸钾（91.909g）；冰浴冷却20分钟后，缓慢滴加吗啉（约30分钟完成）；滴加完毕后移除冰浴，室温搅拌过夜；反应完成后加入水（150mL）淬灭，用5%柠檬酸水溶液调节pH至4-5；静置分层，有机相用水（260mL×1）洗涤，无水MgSO₄干燥半小时，过滤，浓缩滤液并减压干燥得目标化合物。
条件: 氩气保护；冰浴冷却（20分钟）；室温搅拌过夜；
收率: 97.16%（71.9g）
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