1489-97-0 1,4-二氧杂螺[4.5]癸烷-8-羧酸乙酯

运输信息：常温运输。危险描述：非危险化学品。

化学合成。

化学合成

合成路线 1（1. 合成：1489-97-0）

• 步骤: 将4-氧代-环己烷羧酸乙酯（52.8g，0.31mol）、乙二醇（67.4g，1.08mol）和对甲苯磺酸（0.7g）的甲苯（160ml）溶液在室温下搅拌；将仲丁二醇（1.08mol）和对甲苯磺酸（0.7g）加入到4-氧代-环己烷羧酸乙酯（0.31mol）的甲苯（160ml）溶液中，25℃下搅拌20小时。反应完成后，将反应溶液倒入乙醚（300ml）中，加入乙酸乙酯（300ml），分离有机相，依次用水、饱和NaHCO₃水溶液和NaCl溶液洗涤，用Na₂SO₄干燥，真空浓缩，得到产物。
• 条件: With toluene-4-sulfonic acid In toluene at 20 - 25℃; for 20 h; Reflux（部分步骤）
• 收率: 100%
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