33016-47-6 1-三苯甲基咪唑-4-甲醛

中文名称: 1-三苯甲基咪唑-4-甲醛
英文名称: 1-Trityl-1H-imidazole-4-carbaldehyde
CAS号

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名称和标识

中文名: 1-三苯甲基咪唑-4-甲醛
英文名: 1-Trityl-1H-imidazole-4-carbaldehyde
CAS号: 33016-47-6
分子式: C23H18N2O
分子量: 338.4
中文别名: 1-三苯甲基咪唑-4-甲醛
英文别名: 1-Tritylimidazole-4-carboxaldehyde; 1-[1-triphenylmethyl-1H-imidazol-4-yl]carboxaldehyde; (1-triphenylmethyl-1H-imidazol-4-yl)carbaldehyde; 4-Formyl-1-tritylimidazole; 4-formyl-1-triphenylmethyl-1H-imidazole; 4-Formyl-1-trityl-1H-imidazole; 1-(triphenylmethyl)-4-imidazolecarboxaldehyde; 1-(Triphenylmethyl)imidazole-4-carboxaldehyde; 1-Trityl-4-formylimidazole; 1-Trityl-1H-imidazole-4-carboxaldehyde; 1-triphenylmethyl-4-imidazolyl carboxaldehyde; 1-(triphenylmethyl)-1H-imidazole-4-carboxaldehyde

物化属性

LogP: 5.21
LogS: -5.15
MLOGP: 3.16
PSA: 34.89 Å²
SILICOS-IT LogP: 4.54
WLOGP

安全信息

安全说明

运输信息：常温运输。危险描述：非危险化学品，WGK Germany:WGK 3，Hazard Note:Irritant，海关编码:29332900，存储类别:11 - 可燃固体，危险性类别:危害水生环境-长期危害类别4

生产及用途

用途与制备

化学合成

路线1：以1H-咪唑-4-甲醛为原料的N-三苯甲基化反应

步骤：将1H-咪唑-4-甲醛（30.0g，0.30mol）溶于DMF（200mL），冰浴下加入三乙胺（70mL，0.375mol），分批加入三苯基氯甲烷（105g，0.375mol），室温搅拌过夜；真空蒸发混合物，残余物用无水乙醚（4×50mL）洗涤，干燥沉淀得产物。
条件：三乙胺作碱，N,N-二甲基甲酰胺为溶剂，反应温度0-20℃。
收率：100%（100g黄色固体）。
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