化学合成，医药中间体。
医药; 有机合成
合成路线 1（1. 合成：99-81-0）
产率：77%
合成条件：at 40℃; for 6 h; Green chemistry
实验步骤：一般步骤：将卤代炔（0.5mmol），AgF（5mol％）和水（1当量）在TFA（1mL）中的混合物在40℃下搅拌6小时，然后蒸馏出TFA以再次使用。 通过柱色谱分离残余物，得到纯样品。
参考文献：
- [1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375 [2] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254 [3] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986
合成路线 2（2. 合成：99-81-0）
产率：95%
合成条件：With ferric(III) bromide; silica gel In dichloromethane at 20℃; for 0.17 h;
实验步骤：一般步骤：向5mL圆底烧瓶中加入FeCl 3（0.25mmol），硅胶（100mg）和DCM（2mL）。 然后缓慢注入含有α-重氮 - 酮（0.50mmol）的1mL二氯甲烷溶液。 在室温下搅拌10分钟后，将反应混合物真空浓缩，并通过柱色谱法用10：1 PE / EA纯化，得到所需的α-卤代酮。
参考文献：
- [1] Tetrahedron Letters, 2018, vol. 59, # 13, p. 1200 - 1203
合成路线 3（3. 合成：99-81-0）
产率：99%
合成条件：With copper(ll) bromide In ethyl acetate at 60 - 65℃; for 8 h;
实验步骤：2-1-1：α-溴-4-硝基苯乙酮的制备将5g（30.3mmol）4-硝基苯乙酮溶于150ml乙酸乙酯中，并向其中加入13.5g（60.6mmol）溴化铜（II），然后 在反应完成后，将反应液冷却至室温，滤出反应过程中形成的盐。用碳酸氢钠饱和溶液洗涤滤液三次，反应完成后，将反应液冷却至室温。 将该溶液用无水硫酸镁干燥，减压过滤，减压蒸馏，然后在约40℃下真空干燥，得到7.3g（产率：99％）所需化合物，然后直接进行后续反应。 .Mass（M +）：245.1
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