化学合成。
化学合成
合成路线 1(1. 合成:1207-72-3)
产率:97%
合成条件:With sodium hydride In N,N-dimethyl-formamide; mineral oil at 20℃; for 2 h; Cooling with ice
实验步骤:称取NaH(60%纯度,1.0g,25.1mmol)在冰水浴中缓慢加入50ml圆底瓶的DMF(10ml)中,随后加入碘甲烷(1.3g,11.04mmol)和化合物吩噻嗪。 (2g,10.0mmol),转移至室温搅拌2h,TLC监测反应后,加水,用DCM(50ml×3)萃取,硫酸镁干燥,然后浓缩干燥,用硅胶柱1a分离产物(2.1 g),白色固体,熔点:96℃,产率97%。
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