化学合成。
化学合成; 生化试剂
合成路线 1（1. 合成：588-63-6）
产率：90%
合成条件：With potassium carbonate In acetone for 12 h; Reflux
实验步骤：（3-溴丙氧基）苯（26）。 将苯酚（1.0g，10.6mmol）溶于丙酮（20ml）中。 向溶液中加入无水碳酸钾（7.34g，53.1mmol）和1,3-二溴丙烷（8.58g，42.5mmol）。 将反应混合物在油浴中回流12小时。 反应后，通过过滤除去碳酸钾，减压除去溶剂，得到粗产物，然后用乙酸乙酯：己烷（3：7）柱色谱纯化，得到产物26（2.05g，90％）。 1H NMR（400MHz，CDCl3）8 2.24（m，2H），3.54（t，J = 6.4Hz，2H），4.03（t，J = 5.8Hz，2H），6.86（m，3H），7.21（m ，2H）。
参考文献：
- [1] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 3, p. 1244 - 1251 [2] Chemical Communications, 2012, vol. 48, # 52, p. 6517 - 6519 [3] Patent: WO2013/163321, 2013, A1. Location in patent: Paragraph 000181 [4] Dyes and Pigments, 2010, vol. 84, # 2, p. 183 - 189 [5] European Journal of Medicinal Chemistry, 2012, vol. 53, p. 292 - 299 [6] Patent: WO2013/40647, 2013, A1. Location in patent: Page/Page column 17 [7] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 9, p. 1943 - 1948 [8] Patent: CN103664972, 2016, B. Location in patent: Page/Page column 0174; 0175; 0176 [9] Journal of Medicinal Chemistry, 2017, vol. 60, # 5, p. 1734 - 1745 [10] Patent: US2017/183308, 2017, A1. Location in patent: Paragraph 0371; 0372 [11] Journal of Medicinal Chemistry, 2018, vol. 61, # 13, p. 5733 - 5750 [12] Journal of the American Chemical Society, 1922, vol. 44, p. 2649 [13] Arzneimittel-Forschung/Drug Research, 1975, vol. 25, # 12, p. 1853 - 1858 [14] Canadian Journal of Chemistry, 1972, vol. 50, p. 3639 - 3647 [15] Journal of Medicinal Chemistry, 1965, vol. 8, p. 271 - 273 [16] Journal of Medicinal Chemistry, 1965, vol. 8, p. 356 - 367 [17] Tetrahedron Letters, 1993, vol. 34, # 14, p. 2343 - 2346 [18] Journal of Medicinal Chemistry, 1988, vol. 31, # 6, p. 1205 - 1209 [19] Angewandte Chemie, 1995, vol. 107, # 19, p. 2330 - 2333 [20] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 13, p. 2155 - 2158 [21] Journal of Medicinal Chemistry, 2003, vol. 46, # 22, p. 4728 - 4740 [22] Chemistry of Heterocyclic Compounds, 2003, vol. 39, # 9, p. 1218 - 1226 [23] Pharmacy and Pharmacology Communications, 1999, vol. 5, # 8, p. 491 - 494 [24] Journal of Medicinal Chemistry, 2001, vol. 44, # 23, p. 3925 - 3931 [25] European Journal of Medicinal Chemistry, 2009, vol. 44, # 10, p. 4218 - 4226 [26] Archiv der Pharmazie, 2009, vol. 342, # 12, p. 732 - 739 [27] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 17, p. 5145 - 5153 [28] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 5, p. 506 - 511 [29] Inorganica Chimica Acta, 2015, vol. 433, p. 63 - 71 [30] Patent: US2015/284387, 2015, A1. Location in patent: Paragraph 0149 [31] Chemico-Biological Interactions, 2016, vol. 259, p. 154 - 159 [32] European Journal of Medicinal Chemistry, 2017, vol. 125, p. 1279 - 1288 [33] Journal of the American Chemical Society, 2017, vol. 139, # 16, p. 5680 - 5683 [34] European Journal of Medicinal Chemistry, 2018, vol. 159, p. 267 - 276
