695-99-8 2-氯-1,4-苯醌

运输方式：冰袋运输。危险性质：非危险化学品。WGK Germany:3。海关编码:29147000。存储类别:11 - 可燃固体。危险性类别：眼部刺激 类别2，经皮刺激 类别2，特异性靶器官毒性-一次接触，类别3。

化学合成。

化学合成

路线1：

• 原料：二乙酰氧基碘苯（5mmol，1.61g）、NaHSO₄·H₂O（1mmol，0.138g）、苯甲酰胺（1mmol）
• 条件：在水（5ml）和乙腈（5ml）混合溶剂中，20℃搅拌10-15分钟后加入苯甲酰胺，继续搅拌至反应完成（TLC监测）；反应完成后用水淬灭，氯仿（3×10ml）萃取，合并氯仿层用水（3×20ml）洗涤，无水Na₂SO₄干燥，旋转蒸发浓缩，硅胶柱色谱纯化（洗脱剂：乙酸乙酯:己烷=1:9）
• 收率：78%
• 参考文献：Organic Letters, 2010, 12(20), 4644-4647；Synthetic Communications, 2014, 44(4), 468-473

路线2：

• 原料：氢醌1A（220.23mg，2.0mmol）、CAN（0.056g，0.102mmol）、溴酸钠（0.780g，5.17mmol）、无水硅胶（5g）
• 条件：CAN和溴酸钠在H₂O（3mL）中溶液加入无水硅胶，搅拌至自由流动粉末；加入CH₂Cl₂（25mL），缓慢加入氢醌1A的CH₂Cl₂溶液（5mL），加热至回流（40℃）反应2小时（TLC监测）；反应完成后过滤，固体用CH₂Cl₂（3×10mL）洗涤，合并滤液旋转蒸发，径向色谱纯化（洗脱剂：乙酸乙酯:己烷=1:9）
• 收率：82%（注：原数据中收率为82%，但标题写99%可能为笔误）
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