10314-98-4 1-(苄氧羰基)哌啶-4-羧酸

运输信息：常温运输。危险描述：危险等级为IRRITANT（刺激性），非危险化学品，海关编码29333990。

化学合成；生命科学

化学合成；生命科学

合成路线 1（1. 合成：10314-98-4）

• 步骤：向异哌嗪酸（1.29g，10mmol）在CH₃CN/H₂O（2：3,0.1M），NaHCO₃（1.5当量）和Na₂CO₃（1.5当量）的混合物中的溶液中加入（pH~10-11）。将混合物冷却至0℃后，Cbz-Cl（1.42mL，1.7g，10mmol）缓慢加入。在室温下搅拌2小时。反应完成后，通过逐滴加入1N HCl水溶液酸化混合物。然后，蒸发除去CH₃CN，然后用EtOAc（3x）萃取。最后，将合并的有机相用盐水洗涤，用Na₂SO₄干燥，并浓缩，得到所需产物，定量收率，将其不经进一步纯化用于下一反应。
• 条件：With sodium hydrogencarbonate; sodium carbonate In water; acetonitrile at 0 - 20℃; for 2 h;
• 产率：100%
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