化学合成。
医药
合成路线 1（1. 合成：403-21-4）
产率：83%
合成条件：With potassium dichromate; sulfuric acid In acetic acid at 120℃; for 2 h;
实验步骤：将2-氟-4-甲基-1-硝基 - 苯（1.0g，12.9mmol）分批加入到重铬酸钾（5.04g，17.16mmol）在冰醋酸（8mL）中的悬浮液中，然后加入浓硫酸。 酸（3.6毫升）。 将反应混合物加热至120℃，保持2小时，然后冷却至环境温度。 用碎冰淬灭反应，并用乙酸乙酯萃取。 将有机层用盐水洗涤，经无水硫酸钠干燥并真空浓缩，得到3-氟-4-硝基 - 苯甲酸（1.9g，83％），为白色固体。
参考文献：
- [1] Patent: WO2009/130481, 2009, A1. Location in patent: Page/Page column 145 [2] Journal of Medicinal Chemistry, 2005, vol. 48, # 6, p. 1729 - 1744 [3] Patent: EP1820799, 2007, A1 [4] Patent: WO2006/51851, 2006, A1. Location in patent: Page/Page column 60-61 [5] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 5, p. 1386 - 1391 [6] Patent: EP1500643, 2005, A1. Location in patent: Page 39 [7] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 4, p. 1043 - 1046 [8] European Journal of Medicinal Chemistry, 1999, vol. 34, # 3, p. 225 - 234 [9] Patent: US2005/65179, 2005, A1. Location in patent: Page/Page column 9 [10] Patent: US2009/209531, 2009, A1. Location in patent: Page/Page column 5 [11] Patent: US2006/281784, 2006, A1. Location in patent: Page/Page column 8 [12] Bioorganic and Medicinal Chemistry, 2009, vol. 17, # 13, p. 4345 - 4359 [13] Patent: US4483986, 1984, A [14] Patent: WO2004/14905, 2004, A1. Location in patent: Page 157; 157 [15] Journal of the American Chemical Society, 1944, vol. 66, p. 1631 [16] Journal of Medicinal Chemistry, 1983, vol. 26, # 8, p. 1193 - 1196 [17] Patent: US2003/158226, 2003, A1 [18] Patent: US5624957, 1997, A
