化学合成。
化学合成
合成路线 1（1. 合成：3401-47-6）
产率：83%
合成条件：With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 12 h; Inert atmosphere
实验步骤：将7.0g（345.2mmol）中间体M-1和95.4g（690.4mmol）碳酸钾加入到2000mL烧瓶中的1000mL N，N-二甲基甲酰胺中，然后加入32.2ml甲基碘（MeI）（517.7）。 缓慢滴加（mmol）。然后，在氮气流下将混合物在室温下搅拌12小时。将所得混合物加入到3000mL蒸馏水中，过滤结晶的固体，得到中间体M-2（101.1）。 g，83％产量）。
参考文献：
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合成路线 2（2. 合成：3401-47-6）
产率：98%
合成条件：With tris(2,2'-bipyridyl)ruthenium dichloride; carbon tetrabromide In acetonitrile at 20℃; Irradiation
实验步骤：一般步骤：向装有磁力搅拌棒的10mL圆底烧瓶中加入酚类或烯烃（0.1mmol），CBr4（33mg，0.1mmol），无水CH3CN（1mL）和Ru（bpy）3Cl2（3.8mg） ，0.005毫摩尔）。 在室温下将混合物用蓝色LED（1W）照射，通入空气直至原料完全消失（通过TLC监测）。 反应完成后，将溶剂真空浓缩。 通过快速柱色谱法纯化残余物，得到最终产物。
参考文献：
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