化学合成。
化学合成
合成路线 1（1. 合成：13575-75-2）
产率：93.3%
合成条件：With polyphosphoric acid In dichloromethane for 2 h; Reflux
实验步骤：将多磷酸（210g）加入到溶解在二氯甲烷（50mL）中的化合物4（0.19mol，42g）中，并将混合物在回流下加热2小时。 反应完成后，除去溶剂，将残余物缓慢加入碎冰中。 将溶液的pH值调节至7-8，过滤沉淀物并干燥，得到化合物5，为白色固体（36g，93.3％），Mp：94-96℃（点亮：96- 98°C [50]）。 1 H NMR（400MHz，CDCl 3）：δ7.51（s，1H），6.67（s，1H），3.93（s，3H），3.91（s，3H），2.89（t，J = 6Hz，2H）， 2.60（t，J = 6.4Hz，2H），2.15-2.09（m，2H）; 13 C NMR（101MHz，CDCl 3）：δ197.10,153.51,147.96,139.27,125.79,110.22,108.57,55.98,38.50,29.44,23.61。
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