109431-87-0 (R)-1-Boc-3-羟基吡咯烷

中文名称: (R)-1-Boc-3-羟基吡咯烷
英文名称: (R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
CAS号

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名称和标识

中文名: (R)-1-Boc-3-羟基吡咯烷
英文名: (R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine
CAS号: 109431-87-0
分子式: C9H17NO3
分子量: 187.24
中文别名: (R)-(-)-1-Boc-3-羟基吡咯烷,98%
英文别名: (S)-1-N-Boc-3-Hydroxypyrrolidine; (R)-1-tert-Butoxycarbonyl-(−)-3-pyrrolidinol; (S)-(+)-N-BOC-3-pyrrolidinol; R)-(-)-N-Boc-3-pyrrolidinol; (R)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine; N-t-BOC-(R)-3-Hydroxypyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol; (R)-N-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine; (R)-(-)-N-BOC-3-pyrrolidinol; (R)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate; N-BOC-3-hydroxypyrrolidine; tert-butyl (3R)-3-hydroxypyrrolidine-1-carboxylate; MFCD01317838; (S)-1-Boc-3-Hydroxypyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-hydroxypyrrolidine; (R)-Boc-3-hydroxypyrrolidine; tert-Butyl-(3R)-3-hydroxypyrrolidin-1-carboxylat; (R)-1-Boc-3-hydroxy-pyrrolidine; (R)-1-Boc-3-pyrrolidinol; (S)-tert-Butyl 3-hydroxypyrrolidine-1-carboxylate; (R)-1-(tert-Butoxycarbonyl)-3-pyrrolidinol; (R)-1-Boc-3-hydroxypyrrolidine; (S)-1-Boc-3; tert-butyl (3S)-3-hydroxypyrrolidine-1-carboxylate; (R)-(−)-1-Boc-3-pyrrolidinol; (S)-1-Boc-3-pyrrolidinol; 2-Methyl-2-propanyl (3R)-3-hydroxy-1-pyrrolidinecarboxylate; (R)-1-N-BOC-3-HYDROXYPYRROLIDINE

物化属性

外观与性状: 粉末
形态: 粉末
颜色: 白色至类白色
临界压力: 未确定
临界温度: 未确定
储存条件/存储条件

安全信息

安全说明

运输信息：常温运输。危险描述：危险品运输编号UN 3077 9 / PGIII，WGK Germany:3，危险等级IRRITANT，海关编码29339900，存储类别11 - 可燃固体，危险性类别危害水生环境-急性危害类别1，眼部刺激类别2，经皮刺激类别2，特异性靶器官毒性-一次接触类别3。

生产及用途

用途与制备

化学合成，手性试剂；N-叔丁氧羰基-(R)-3-吡咯烷醇用作医药中间体，用于合成烟碱乙酰胆碱受体的配体。

医药

合成路线 1（1. 合成：109431-87-0）

产率：100%
合成条件：With triethylamine In 1,4-dioxane
实验步骤：3k，化合物16的合成是四个反应过程。首先，得到化合物16b，为（R）-3-吡咯烷醇（539mg，6.19mmol）的无色油状物（1.3g，100％）。光谱数据与提出的结构一致，并与文献中报道的相匹配。从化合物16b获得化合物16c，为无色油状物。从化合物16c两步获得化合物16e，为无色油状物。最后，从化合物16e获得化合物16，为黄色油状物。
参考文献：[1] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 10, p. 969 - 973 [2] Patent: WO2015/9731, 2015, A2. Location in patent: Paragraph 00106 [3] Journal of Medicinal Chemistry, 1998, vol. 41, # 25, p. 4983 - 4994 [4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 17, p. 5812 - 5832 [5] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 86 [6] Patent: WO2004/37797, 2004, A2. Location in patent: Page 176 [7] ChemMedChem, 2014, vol. 9, # 7, p. 1476 - 1487 [8] Patent: CN105153133, 2018, B. Location in patent: Paragraph 0022; 0023; 0024; 0027; 0028 [9] Patent: EP1950198, 2008, A1. Location in patent: Page/Page column 14 [10] Journal of the American Chemical Society, 2002, vol. 124, # 51, p. 15267 - 15279 [11] Angewandte Chemie - International Edition, 2018, vol. 57, # 37, p. 12102 - 12105 [12] Angew. Chem., 2018, vol. 130, p. 12278 - 12281,4 [13] Patent: EP2803664, 2014, A1. Location in patent: Paragraph 0136; 0137 [14] Patent: US2015/5282, 2015, A1. Location in patent: Paragraph 0194; 0195 [15] Chemische Berichte, 1997, vol. 130, # 3, p. 385 - 397 [16] Patent: WO2006/50940, 2006, A1. Location in patent: Page/Page column 56 [17] Patent: US2001/14691, 2001, A1 [18] Patent: US2001/31771, 2001, A1 [19] Patent: WO2006/40625, 2006, A1. Location in patent: Page/Page column 47 [20] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 1, p. 170 - 174 [21] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4601 - 4608 [22] Patent: WO2011/160020, 2011, A2. Location in patent: Page/Page column 65 [23] Patent: EP1550660, 2005, A1. Location in patent: Page/Page column 9 [24] Patent: WO2008/133734, 2008, A2. Location in patent: Page/Page column 39-40

109431-87-0 (R)-1-Boc-3-羟基吡咯烷 - 化工 AI 网

109431-87-0 (R)-1-Boc-3-羟基吡咯烷

109431-87-0 (R)-1-Boc-3-羟基吡咯烷

名称和标识

物化属性

安全信息

生产及用途

合成路线 1（1. 合成：109431-87-0）

合成路线 2（2. 合成：109431-87-0）

合成路线 3（3. 合成：109431-87-0）