化学合成。
医药; 有机合成
合成路线 1（1. 合成：66572-56-3）
产率：88%
合成条件：at 20 - 50℃; for 2 h;
实验步骤：向搅拌的29.0g（69mmol）2-溴-4-甲基吡啶在150mL浓硫酸中的溶液中分批加入67.9g（231mmol）重铬酸钾。用冰浴冷却反应混合物，使温度保持恒定。 加完后，在室温下继续搅拌2小时。然后将反应混合物缓慢倒入2L冰水中，室温下搅拌混合物1小时。 过滤收集所得晶体，用水洗涤直至洗液无色，真空干燥，得到30.0g（88％）2-溴异烟酸。
参考文献：
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