55750-48-6 2,5-二氧代-2,5-二氢-1H-吡咯-1-羧酸甲酯

危险性质：否

化学合成

化学合成

合成路线 1（1. 合成：55750-48-6）

• 产率：88%
• 合成条件：With 4-methyl-morpholine In ethyl acetate at 0 - 20℃; for 1.50 h;
• 实验步骤：在0℃下，向马来酰亚胺（6.35g，65.4mmol）的乙酸乙酯（120mL）溶液中加入NMM（8.6mL，78.5mmol），然后加入氯甲酸甲酯（6.0mL，78.5mmol）。 将反应在0℃下搅拌30分钟并在室温下搅拌1小时。滤出固体，浓缩滤液。 将残余物溶于二氯甲烷中，通过硅胶塞过滤，用二氯甲烷洗脱，除去红色。 浓缩后，将固体用乙酸乙酯和石油醚研磨，得到白色固体（9.0g，收率88％）。
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