化学合成。
化学合成
合成路线 1（1. 合成：33301-41-6）
产率：100%
合成条件：With triethylamine In dichloromethane at 0℃; for 2 h;
实验步骤：甲磺酸1-二苯甲基 - 氮杂环丁烷-3-基酯（12）（方案5，步骤8）。 在氮气下，在0℃（冰 - 水浴）下，向1-二苯甲基 - 氮杂环丁烷-3-醇（15.0g，62.7mmol）的无水CH 2 Cl 2（1mL）溶液中加入干燥的Et 3 N（25mL，94.0mmol））。 然后通过加压均流加料漏斗向其中滴加甲磺酰氯（5.8mL，75.2mmol）的无水CH 2 Cl 2（50mL）溶液。 加完后，移去冷却浴，搅拌混合物2小时。 将非均相混合物用H 2 O（70mL）处理，分离各层，水层用CH 2 Cl 2（2.x.100mL）萃取。 将合并的有机萃取液干燥（MgSO 4），过滤并浓缩，得到澄清无色油状物。 加入己烷（100mL）后，粘稠的油状产物固化并通过真空过滤收集。 在高真空下干燥，得到19.7g（100％收率）12，为无色固体。
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