化学合成，医药氟罗沙星中间体；生化研究。
医药
合成路线 1（1. 合成：383-50-6）
产率：100%
合成条件：With 4-methyl-morpholine In dichloromethane at 20℃; for 17 h;
实验步骤：向反应容器中加入2-氟乙醇（1.00mL，16.9mmol），对甲苯磺酰氯（3.85g，20.2mmol），N-甲基吗啉（9.30mL，84.5mmol）和CH 2 Cl 2（50mL），进行反应。 在室温下保持17小时。 反应后，将水加入到反应体系中，用乙酸乙酯将产物萃取三次到有机层中。 用饱和盐水洗涤所得有机层并用MgSO 4干燥。 减压浓缩后，浓缩物经Hi-flash硅胶柱色谱纯化（展开溶剂，乙酸乙酯：己烷= 19：81→40：60），得到产物（3.79g（17.2mmol），产率> 100％， 淡黄色液体）。 114-NMR（600MHz，CDCl 3）：δ7.81（d，J = 8.4Hz，2H），7.36（d，J = 8.4Hz，2H），4.63-4.60（m，1H），4.55-4.52（m ，1H），4.31-4.27（m，1H），4.26-4.23（m，1H），2.46（s，3H）; 计算出的C 9 H 11 F 3 O（Mt）的LRMS（EI）：218.0，实测值：218.0。
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