化学合成，作为结构单元用于高效钯催化合成2-吡啶基氮杂薁，这是一种表现出pH和阳离子金属依赖性发射光谱的双齿配体。
化学合成
合成路线 1（1. 合成：17997-47-6）
产率：100%
合成条件：Stage #1: With n-butyllithium In tetrahydrofuran at -70℃; for 0.50 h; Inert atmosphere Stage #2: at -70℃; for 2 h;
实验步骤：向2-溴吡啶（XCVI）（10g，63mmol，1.00当量）的THF（150mL）溶液中加入n-BuLi（25.3mL，63mmol，1.00当量），并将混合物在-70°搅拌 在氮气氛下30分钟。 然后加入n-Bu 3 SnCl（21.7g，67mmol，1.06当量），将混合物在相同温度下再搅拌2小时。 向溶液中加入饱和氯化铵溶液（150mL），用乙酸乙酯（150mL×3）萃取。 将合并的有机层用Na 2 SO 4干燥，过滤并真空浓缩，得到粗制2-（三丁基甲锡烷基）吡啶（XCVII）（25.9g，63mmol，100％收率），为黄色油状物。 粗产物无需进一步纯化即可使用。
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