N-异丙基氯乙酰氨主要用于医药领域(具体用途未在提供数据中详细说明)
医药
合成路线 1(1. 合成:2895-21-8)
产率:70.3%
合成条件:With potassium carbonate In dichloromethane at 20℃; Cooling with ice
实验步骤:将异丙胺(236.4mg,4.0mmol)溶于4mL二氯甲烷中,加入无水碳酸钾(663.4mg,4.8mmol)。将反应烧瓶置于冰浴中,氯乙酰氯(451.8mg,4.0mmol)缓慢加入 通过滴液漏斗加入,将反应物在室温下搅拌过夜。 反应完成后,加入10mL冰水以淬灭反应,二氯甲烷,合并的有机相用饱和盐水洗涤,用无水硫酸镁干燥,减压蒸馏,无需进一步纯化,得到白色固体。 产率:70.3%
参考文献:
- [1] Journal of Organic Chemistry, 2012, vol. 77, # 9, p. 4261 - 4270 [2] Journal of the American Chemical Society, 2009, vol. 131, p. 1106 - 1114 [3] ChemistryOpen, 2014, vol. 3, # 6, p. 238 - 241 [4] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 6, p. 678 - 681 [5] Patent: CN106146414, 2016, A. Location in patent: Paragraph 0472; 0473; 0474 [6] Journal of the American Chemical Society, 1956, vol. 78, p. 2556,2557 [7] Journal of the American Chemical Society, 1953, vol. 75, p. 918 [8] Tetrahedron Letters, 2009, vol. 50, # 36, p. 5123 - 5125 [9] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 21, p. 6310 - 6312 [10] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 6, p. 1479 - 1483 [11] RSC Advances, 2015, vol. 5, # 60, p. 48368 - 48381 [12] Patent: WO2016/210331, 2016, A1. Location in patent: Paragraph 0089; 0090 [13] Patent: WO2016/210330, 2016, A1. Location in patent: Paragraph 0093-0094 [14] Patent: CN106167497, 2016, A. Location in patent: Paragraph 0119; 0120 [15] Bulletin of the Korean Chemical Society, 2018, vol. 39, # 2, p. 146 - 155 [16] Molecules, 2018, vol. 23, # 5,