2436-29-5 3-(1,3-二氧代异吲哚啉-2-基)丙醛

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合成路线 3（3. 合成：2436-29-5）

产率：91.4% 合成条件：With hydrogenchloride; water; acetic acid In tetrahydrofuran at 20 - 50℃; for 2 h; 实验步骤：在四氢呋喃（12ml）和乙酸（4ml）的混合溶剂中溶解2- [2-（1,3-二氧戊环-2-基）乙基] -1H-异吲哚-1,3（2H） - 二酮 （728mg，2.94mmol），然后在室温下向其中加入2M盐酸水溶液（5ml），并将所得混合物在50℃下搅拌2小时。 反应完成后，将反应溶液用乙酸乙酯萃取。 依次用水，饱和碳酸氢钠水溶液和饱和氯化钠水溶液洗涤有机层，然后用无水硫酸钠干燥。 减压蒸馏除去溶剂，用己烷 - 乙醚混合溶剂洗涤得到的固体，得到标题化合物（546mg，91.4％）。 1H-NMR（DMSO-d6）9.65（br，1H），7.80-7.88（m，4H），3.84（t，2H，J = 4.4Hz），2.79（dt，2H，J = 1.5,6.9Hz）。 参考文献：

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