2483-46-7 (S)-2,6-二叔丁氧羰基氨基己酸

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合成路线 3（3. 合成：2483-46-7）

产率：93% 合成条件：With triethylamine In 1,4-dioxane; water for 18 h; Cooling with ice 实验步骤：将Nα-（叔丁氧基羰基）-L-赖氨酸（1）（985mg，4mmol）溶于无水1,4-二恶烷（3mL）和水（3mL）中。加入三乙胺（615μL，4.4mmol）后，在冰冷却下向该溶液中滴加二碳酸二叔丁酯（960mg，4.4mmol），然后将混合物搅拌18小时。通过TLC（乙酸乙酯：正己烷= 5：1）确认反应完成，并将反应溶液倒入0.5N盐酸水溶液（80mL）中。用乙酸乙酯（3×40mL）萃取混合物，用饱和盐水（80mL）洗涤有机层，用无水硫酸镁干燥。减压蒸发后，通过快速柱色谱法（乙酸乙酯：正己烷= 1：1至2：1）纯化所得物质，得到中间体2（1.29g，93％），为白色固体。 1H-NMR（300MHz，CDCl3）δ：5.21（br s，1H），4.62（br s，1H），4.28（br s，1H），3.14（d，2H，J = 6.0Hz）， 1.88（br s，1H），1.76（br s，1H），1.45-1.23（m，22H），0.92-0.88（m，1H）。 参考文献：

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